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This function is particularly relevant in neurons, where sHSPs frequently colocalize with disease-associated protein aggregates and serve as an early line of defense against proteotoxic stress

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[297] found Amuc_2109 (-N-acetylhexosaminidase from Akk ) improved DSS-induced colitis as evidenced by lowered DAI, reduced weight loss, and increased colon length

Furthermore, these processes accelerate cardiomyocyte aging, compounding the risk of heart failure (50, 88)

The expressions of SIRT-1 and CYP2E1 were normalized to the expression of the endogenous control GAPDH